Stent with guideliner
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9 Even DESs with biodegradable polymer coatings intended to limit the inflammatory response resulting from prolonged polymer degradation have not shown conclusive improvements in clinical outcomes. 8 These contribute to late DES failure including restenosis and stent thrombosis. 6, 7 Contemporary DES have emphasized prolonged antiproliferative drug delivery to suppress smooth muscle cell proliferation to mitigate the vasculoproliferative response to arterial injury, which delays endothelialization and may be associated with hypersensitivity reactions and neoatherosclerosis. 2–5 Despite significant improvements, repeated intervention is required at an annual rate of 2% to 3% and life-threatening late and very-late stent thrombosis persists. New or second-generation drug-eluting stents (DESs) reduce device-related adverse clinical outcomes, including target lesion revascularization and stent thrombosis, compared with bare-metal stents, 1 and are the current standard of care for patients undergoing percutaneous coronary intervention (PCI) across the spectrum of coronary syndromes. Customer Service and Ordering Information.
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Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).